beat·365(中国)-九游会ag

研究领域与方向

西药与植物提取化合物抗肿瘤与抗前列腺肥大药理机制研究

科研课题（主要承担和参与的科研项目）

1.2019年江西省教育厅科技项目,甲基莲心碱及衍生物经细胞凋亡抗前列腺癌机制研究，在研，主持

2.2019年度宜春学院地方发展研究中心平台项目,多靶点活性化合物抗良性前列腺增生平台构建,在研,主持

3.台湾省教育部门,quinazoline类药物干扰ngf/trka/p75ntr讯息传递抑制摄护腺细胞生长,已结题，主持

4.台湾省教育部门,鱼油抑制摄护腺癌细胞之toll like receptor 9讯息传递所引起的发炎反应与癌转移,已结题，主持

5.台湾省教育部门,生姜活性萃取物于抗药性摄护腺癌之开发,已结题，主持

6.台湾省教育部门,鱼油抵抗摄护腺癌细胞之toll like receptor 4讯息传递所引起的发炎反应与降低化疗药物的抗性，已结题，主持

7.zbtb-1蛋白在乳腺癌干细胞和化疗抗性中的作用及其机制研究,在研，参与

8.notch1 通路在一枝黄花提取物抗肿瘤活性的作用,在研，参与

代表性学术论著 (译著、教材)、论文

一、第一或通讯作者发表的主要学术论文

1. chi-ming liu^*# ,zhengping wu^#, bo pan, lijie an, conglei zhu, jiqin zhou, yinjie jiang. the antiandrogenic effect of neferine, liensinine, and isoliensinine by inhibiting 5-α-reductase and androgen receptor expression via pi3k/akt signaling pathway in prostate cancer. pharmazie, 2021;76(5):225-231.

2. lijie an*, zichen shao, mengqiao su, chi-ming liu*. the traditional chinese medicine in the treatment of severe acute respiratory syndrome coronavirus 2.

chinese traditional medicine journal, 2021;4(1):1-11

3. zhenping wu, chung-yi chen, chiu-li kao, yinjie jiang, chi-ming liu*. docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic activities by decreasing inflammation on prostate cancer cell. pharmazie, 2019;74(11):675-679.

4. chung-yi chen, chiu-li kao, chi-ming liu*. the cancer prevention, anti-inammatory and anti-oxidation of bioactive phytochemicals targeting the tlr4 signaling pathway. international journal of molecular sciences, 2018;19(9):2729.

5. chi-ming liu, mei-hui perng, chung-yi chen. the antioxidation and antiproliferation activity of flavonoids from aquilaria agallocha and aquilaria sinensis. biomedical research, 2018;29 (10):2191-2196

6. chi-ming liu, mei-hui perng*, chung-yi chen*. antioxidant activities of crude extracts from peel and seed of cinnamomum camphora. biomedical research, 2018;29 (13):2854-2858

7. chiu-li kao ^#, ying chen hung^#, chi-ming liu*. the pharmacological effect of omega-3 fatty acids prevent cancer progression in colon and breast cancer. austin journal of nutrition and food sciences, 2017; 5(2): 1090.

8. mei-yin chang^#, chi-ming liu^#, den-en shieh, chung-yi chen*. evaluation and analysis of phytochemical antioxidant capacity. biomedical research, 2017;28 (14):6431-6434.

9. chi-ming liu, chiu-li kao, yu-ting tseng, yi-ching lo*, chung-yi chen*. ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cell. molecules, 2017;22(9):1477.

10. liang-chien she^#, chi-ming liu^#, ching-tong chen, hsing-tan li, wei-jen li*, chung-yi chen*. the anti-cancer and anti-metastasis effects of phytochemical constituents

from leucaena leucocephala. biomedical research, 2017;28(7):2893-2897

11. chi-ming liu, hung-chun yeh, song-chih huang, cheng-ta li* and chung-yi chen*. the antioxidation and antiproliferation activity of new flavonoids from the leaves and stems of cinnamomum reticulatum hayate. medicinal chemistry, 2015:5(2):064-066

12. chi-ming liu, chiu-li kao, hui-ming wu, wei-jen li, cheng-tsung huang*, hsing-tan li* and chung-yi chen*. antioxidant and anticancer aporphine alkaloids from the leaves of nelumbo nucifera gaertn. cv. rosa-plena. molecules, 2014; 19:17829-17838

13. chi-ming liu, ya-chin fan, yi-ching lo, bin-nan wu, jwu-lai yeh, ing-jun chen*. cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/rho kinase ii-activation in benign prostate hyperplasia. international journal of urology, 2013;21(1):87-92.

14. hsing-tan li, hui-ming wu, hsin-liang chen, chi-ming liu*, chung-yi chen*. the pharmacological activities of (−)-anonaine. molecules, 2013;18:8257-8263.

15. chi-ming liu, yi-ching lo, ming-hong tai, bin-nan wu, wen-jeng wu, yii-her chou, chee-yin chai, chun-hsiung huang, ing-jun chen*. piperazine-designed alpha(1a)/alpha(1d)-adrenoceptor blocker kmup-1 and doxazosin provide down-regulation of androgen receptor and psa in prostatic lncap cells growth and specifically in xenografts. prostate, 2009; 69(6): 610-623.

16. chi-ming liu, yi-ching lo, bin-nan wu, wen-jeng wu, yii-her chou, chun-hsiung huang, li-mei an, and ing-jun chen*. cgmp-enhancing- and α1a/α1d-adrenoceptor blockade-derived inhibition of rho-kinasebykmup-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy. prostate, 2007;67(13):1397-1410.

二、教材

1.解剖生理学 作者：邓志娟,冯琮涵,刘棋铭,吴惠敏,唐善美,许淑芬,江若华,黄嘉惠,汪蕙兰,李建兴,王子绫, 利瓦伊贞, 庄礼聪 出版社：新文京

2.新护理师宝典病理学 作者：林靖蓉,高久理,刘棋铭编着 出版社：永大