beat·365(中国)-九游会ag

姓    名

张昌源

性    别

男

出生年月

1988.05.16

学科专业

药物研发与生产技术

毕业院校

华南理工大学

学   位

博士研究生

职    称

讲师

现任职务

联系电话

18979597115

电子邮件

zcywood@163.com

研究领域与方向

合成方法学的建立及其在药物分子修饰中的应用

科研课题（主要承担和参与的科研项目）

1. 基于tf2o/m介导烯胺酮选择性构建氮杂环的反应研究，国家自然科学基金（地区基金），22361045，32万，2024.1-2027.12，主持,在研。

2. 基于三氟甲磺酸活化烯胺酮的串联反应研究，江西省教育厅科学技术研究项目，gjj2201726,3万，2023.1-2024.12，主持，在研。

3. 基于磷自由基参与的环己炔双磷化反应研究，国家自然科学基金（青年基金），21901223，21万，2020.1-2022.12，主持，结题。

4. 环炔前体的制备以及环炔的磺酰自由基加成反应研究，江西省教育厅科学技术研究项目，gjj180839，3万，2019.1-2020.12，主持，结题。

5. 基于炔烃的串联反应研究（博士启动项目）主持。

代表性学术论著 (译著、教材)、论文

1. changyuan zhang,* wei wang, xuncheng zhu, lulu chen, hejiang luo,* mengping guo, dan liu, fan liu, huisheng zhang, qi li, and jianping lin, synthesis of indolizines via tf2o‑mediated cascade reaction of pyridyl-enaminones with thiophenols/thioalcohols org. lett. 2023, 25, 1192−1197;

2. changyuan zhang,* jian luo, jiantao zhang, lulu chen, xuncheng zhu, mengping guo, chan shen, zeng li, and wei wang, tf2o-mediated regioselective c(sp2) h sulfenylation of enaminones using methyl sulfoxides as sulfur sources, asian j. org. chem. 2022, 11, e202200014;

3. changyuan zhang,* huosheng guo, lulu chen,* jiantao zhang, mengping guo, xuncheng zhu, chan shen, and zeng li, one-pot synthesis of symmetrical and asymmetrical 3‑amino diynes via cu(i)-catalyzed reaction of enaminones with terminal alkynes, org. lett. 2021, 23, 8169−8173;

4. changyuan zhang,* yun qiu, jiantao zhang, lulu chen, shuting xu, huosheng guo, jian luo, and yao tan, can-mediated oxidative coupling-reaction of xanthenes with enaminones, asian j. org. chem. 2021, 10, 160-163;

5. changyuan zhang, lianfen chen, kai chen, chuntao wang, zurong xu, huanfeng jiang and shifa zhu, cu(i)-catalyzed stereoselective synthesis of trisubstituted z-enol esters via interrupting the 1,3-o-transposition reaction, org. chem. front., 2018, 5, 2510-2514;

6. changyuan zhang, lianfen chen, kai chen, huanfeng jiang and shifa zhu, iron/zinc-catalyzed benzannulation reactions of 2-(2-oxo-alkyl)benzketones leading to naphthalene and isoquinoline derivatives, org. chem. front., 2018, 5, 1028-1033;

7. changyuan zhang, huanfeng jiang and shifa zhu, gold-catalyzed ring-expansion through acyl migration to afford furan-fused polycyclic compounds, chem. commun., 2017, 53, 2677-2680;

8. lili chen, changyuan zhang, chunxiao wen, kun zhang, wenfeng liu, qian chen, gold-catalyzed cyclotrimerization of arynes for the synthesis of triphenylenes; catalysis communications 65 (2015) 81-84;

9. qian chen, changyuan zhang, chunxiao wen, jin fang, zhiyun du, dongling wu, platinum- and gold-catalyzed hydroalkoxylation and tetramerization of propiolate esters, catalysis communications 56 (2014) 101-105;

10. qian chen, changyuan zhang, lili chen, chunxiao wen, zhiyun du, huixiong chen, kun zhang, a-monoarylation and tandem arylation–insertion of malonates with arynes, tetrahedron letters 56 (2015) 2094-2097;

11. tian-yu sun, kai chen, changyuan zhang, tingting you, and penggang yin, 1,3-o-transposition or trisubstituted z-enol ester? a comparative study of reactions of ynones, chem. asian j. 2019, 14, 1941-1944;

12. jingcheng du, changyuan zhang, hong pu, yufeng li, saimeng jin, luxi tan, cailong zhou, lichun dong; hkust-1 mofs decorated 3d copper foam with superhydrophobicity/superoleophilicity for durable oil/water separation, colloids and surfaces a 573 (2019) 222-229.

学术兼职及荣誉称号

学术兼职：the journal of organic chemistry杂志审稿人

2019年度科研工作先进个人；2019-2020学年度优秀教师

发明专利及获奖情况

一种苯基硫代二苯磷酸酯的制备方法，cn 110563760 b, 2022.2.11 (授权发明专利)